Publications

The DarTG toxin-antitoxin system provides phage defence by ADP-ribosylating viral DNA.

LeRoux, M., Srikant, S., Teodoro, G.I.C,. Zhang, T., Littlehale, M.L., Doron, S., Badiee, M., Leung, A.K.L., Sorek, R., Laub, M.T.

(2022) Nature Microbiology, Jul;7(7):1028-1040. https://doi.org/10.1038/s41564-022-01153-5

Publications can also be viewed at pubmed.

Toxin-Antitoxin Systems as Phage Defense Elements.

LeRoux, M., Laub, M.T.

(2022) Annual Review of Microbiology. Apr 8. doi: 10.1146/annurev-micro-020722-013730.

Stress Can Induce Transcription of Toxin-Antitoxin Systems without Activating Toxin.

LeRoux, M., Culviner, P. H., Liu, Y. J., Littlehale, M. L., & Laub, M. T.

(2020). Molecular Cell, 79(2), 280-292.e8.

Bacterial Danger Sensing.

LeRoux, M., Peterson, S.B., Mougous, J.D.

(2015) Bacterial Danger Sensing. Journal of Molecular Biology. 427(23), 3744-53.

An interbacterial NAD(P)+ glycohydrolase toxin requires elongation factor Tu for delivery to target cells.

Whitney, J.C., Quentin, D., Sawai, S., LeRoux, M., Harding, B.N., Ledvina, H.E., Tran B., Robinson, H., Goo Y.A., Goodlett, D.R., Raunser, S., and Mougous, J.D.

(2015) Cell. 163(3), 607-19.

A self-lysis pathway that enhances the virulence of a pathogenic bacterium.

McFarland, K. A., Dolben, E. L., LeRoux, M., Kambara, T. K., Ramsey, K. M., Kirkpatrick, R. L., Mougous J.D., Hogan D.A., and Dove S.L.

(2015) Proceedings of the National Academy of Sciences. 112(27), 8433-8438.

Lysis of kin cells is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa.

LeRoux, M., Kirkpatrick, R.L., Montauti E.I., Peterson S.B., Harding B.N., Whitney, J.C., Russell A.B., Traxler, B., Goo, Y.A., Goodlett, D.R., Wiggins, P.A., and Mougous, J.D.

(2015) eLife. 4, e05701.

Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors.

Russell, A. B., LeRoux, M., Hathazi, K., Agnello, D. M., Ishikawa, T., Wiggins, P. A., Wai, S.N., and Mougous, J.D.

(2013). Nature. 496(7446), 508-512.

Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword.

LeRoux, M., De Leon, J. A., Kuwada, N. J., Russell, A. B., Pinto-Santini, D., Hood, R. D., Agnello, D.M., Robertson, S.M., Wiggins, P.A., and Mougous, J.D.

(2012). Proceedings of the National Academy of Sciences, 109(48), 19804–19809.

Structure of a Peptidoglycan Amidase Effector Targeted to Gram-Negative Bacteria by the Type VI Secretion System.

Chou S., Bui N.K., Russell A.B., Lexa K., Gardiner, T., LeRoux M., Vollmer W., Mougous J.D.

(2012) Cell Reports 1, 1–9.

Type VI secretion delivers bacteriolytic effectors to target cells.

Russell A.B., Hood R.D., Bui N.K., LeRoux M., Vollmer W., Mougous J.D.

(2011) Nature. 475(7356), 343-347.

A non-radioactive DAPI-based high-throughput in vitro assay to assess Plasmodium falciparum responsiveness to antimalarials.

Ndiaye, D., Patel, V., Demas, A., LeRoux, M., Ndir, O., Mboup, S., Clardy, J., et. al.

(2010). The American journal of tropical medicine and hygiene, 82(2), 228–230.

Plasmodium falciparum biology: analysis of in vitro versus in vivo growth conditions.

LeRoux, M., Lakshmanan, V., & Daily, J. P.

(2009). Trends in parasitology, 25(10), 474–481.